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. 2012 Aug 21;48(65):8111-3.
doi: 10.1039/c2cc33743f. Epub 2012 Jul 6.

Enantioselective synthesis of levomilnacipran

Julien Alliot  1 , Edmond Gravel, Florence Pillon, David-Alexandre Buisson, Marc Nicolas, Eric Doris
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Enantioselective synthesis of levomilnacipran

Julien Alliot et al. Chem Commun (Camb). .

Abstract

A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.

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