Regulatory T cells expressing PPAR-γ control inflammation in obesity
- PMID: 22768833
- DOI: 10.1016/j.cmet.2012.06.007
Regulatory T cells expressing PPAR-γ control inflammation in obesity
Abstract
A recent study (Cipolletta et al., 2012) shows that regulatory T (Treg) cells expressing the peroxisome-proliferator- activated receptor (PPAR-γ) are engaged in suppressing adipose tissue inflammation in obesity, suggesting that Treg cells may be a target for treatment and prevention of adipose tissue inflammation and insulin resistance.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.Nature. 2012 Jun 28;486(7404):549-53. doi: 10.1038/nature11132. Nature. 2012. PMID: 22722857 Free PMC article.
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