Naproxen parenteral formulation studies
Affiliations
- PMID: 2277322
Item in Clipboard
Naproxen parenteral formulation studies
J Parenter Sci Technol.
1990 Nov-Dec.
Abstract
Naproxen sodium has been formulated in a parenteral dosage form. After a series of experiments involving solubility, pH, and excipient compatibility using Placket Burman experimental design, the formulation has been finalized. The accelerated stability studies on samples stored at high temperatures projected the shelf life to be 4.2 years. Toxicological, therapeutic efficacy, and other aspects of this formulation are being reported separately.
Similar articles
-
Formulation development of frozen parenteral dosage forms.J Parenter Sci Technol. 1992 Jul-Aug;46(4):124-9. J Parenter Sci Technol. 1992. PMID: 1453281
-
Miniaturized approach for excipient selection during the development of oral solid dosage form.J Pharm Sci. 2014 Mar;103(3):900-8. doi: 10.1002/jps.23840. Epub 2014 Jan 16. J Pharm Sci. 2014. PMID: 24436033
-
[Difficulties encountered during formulation of a parenteral dosage form containing a poorly soluble drug].Acta Pharm Hung. 2009;79(1):35-44. Acta Pharm Hung. 2009. PMID: 19526681 Hungarian.
-
Formulation of Neulasta (pegfilgrastim).Adv Drug Deliv Rev. 2008 Jan 3;60(1):50-8. doi: 10.1016/j.addr.2007.04.017. Epub 2007 Aug 11. Adv Drug Deliv Rev. 2008. PMID: 17822802 Review.
-
MT 100.Drugs R D. 2003;4(1):57-8. doi: 10.2165/00126839-200304010-00011. Drugs R D. 2003. PMID: 12568640 Review. No abstract available.