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. 2012;5(3):397-400.
doi: 10.3980/j.issn.2222-3959.2012.03.29. Epub 2012 Jun 18.

Meta analysis on the relationship between gene polymorphisms of vascular endothelial growth factor and retinal prognosis risk of prematurity

Jun Zhai  1 , Qiu-Hui Jiang, Chun-Xi Liu, Zuo-Rong Tian, Ying-Pu Sun
Affiliations

Meta analysis on the relationship between gene polymorphisms of vascular endothelial growth factor and retinal prognosis risk of prematurity

Jun Zhai et al. Int J Ophthalmol. 2012.

Abstract

Aim: To explore the relationship between gene polymorphisms of vascular endothelial growth factor (VEGF) and retinopathy of prematurity (ROP).

Methods: Literature materials related to gene polymorphisms of VEGF and ROP in PubMed, EMBASE, Cochrane and CBM database were retrieved. These materials were screened according to inclusion and exclusion standards. Patients diagnosed with ROP in clinic were regarded as control group and ROP patients who were in treatment were regarded as observation group. The indexes in two groups were matched except birth weight (BW), gender and gestational weeks. Meta5.1 was used to analyze the relationship between gene polymorphisms of VEGF and ROP.

Results: Four random control tests (RCT) were included in this research, including 2611 patients. Meta analysis results showed that VEGF affected ROP, having statistical significance. The combined ratio was 0.44 (95%CI, 0.07, 0.80), 0.42 (95%CI, 0.09, 0.74) and 0.75 (95%CI, 0.02, 1.49), respectively. Carrying +405 allele might increase the premature infants' risk of having ROP.

Conclusion: ROP may be related to its carrying of +405 allele. Large-scale, multi-factor RCT researches are still needed in order to identify the relation between VEGF and ROP.

Keywords: Meta analysis; polymorphisms of vascular endothelial growth factor; premature infant; retinopathy.

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Figures

Figure 1
Figure 1. Meta analysis on genetype GG at +405G/C locus and ROP.
Figure 2
Figure 2. Bias analysis for the influence of genetype GG at +405G/C locus on ROP.
Figure 3
Figure 3. Bias analysis for the influence of genetype GC at +405G/C locus on ROP.
Figure 4
Figure 4. Results of Meta analysis on genetype GC at +405G/C locus and ROP.
Figure 5
Figure 5. Meta analysis on genetype CC at +405G/C locus and ROP.
Figure 6
Figure 6. Bias analysis for the influence of genetype CC at +405G/C locus on ROP.
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