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. 2012;5(3):401-5.
doi: 10.3980/j.issn.2222-3959.2012.03.30. Epub 2012 Jun 18.

Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer's disease: a meta-analysis

Xue-Fei He  1 , Yi-Ting Liu, Cheng Peng, Fan Zhang, Shi Zhuang, Jin-Song Zhang
Affiliations

Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer's disease: a meta-analysis

Xue-Fei He et al. Int J Ophthalmol. 2012.

Abstract

Aim: To investigate the difference of retinal nerve fiber layer (RNFL) thickness between Alzheimer's disease patients and normal people, so as to provide clue for the early diagnosis of Alzheimer's disease.

Methods: The articles on the association of RNFL thickness and Alzheimer's disease were retrieved by searching international and national databases. The qualified articles were assessed by meta analysis with Stata11.0 software. The results were pooled using weighted mean difference (WMD) with a corresponding 95% confidence interval (CI).

Results: Totally 7 studies enrolled 324 eyes were included in the meta-analysis. The results of meta analysis showed that in AD patients, there was a significant average RNFL thickness reduction compared with the control group [WMD=-17.561, 95%CI: (-23.971, -11.151)]. There were significant differences in superior, inferior, nasal and temporal RNFL thickness between the two groups. WMD with a 95%CI were [-18.829, 95%CI:(-25.915, -11.743); P<0.05], [-25.775, 95%CI:(-34.304, -17.247); P<0.05], [-16.877, 95%CI: (-29.141, -4.613); P<0.001] and [-14.565, 95%CI:(-28.002, -1.128); P<0.001] respectively. Begg's test and Egger's test did not show significant difference, funnel plot was basically symmetrical, indicating that there was no publication bias existed.

Conclusion: There are significant differences in the RNFL thickness in all quadrants between the two groups. RNFL thickness is reduced in AD patients compared with the control group.

Keywords: Alzheimer's disease; meta analysis; optical coherence tomography; retinal nerve fiber layer thickness.

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Figures

Figure 1
Figure 1. Meta-analysis of average RNFL thickness between patients and healthy controls.
Figure 2
Figure 2. Meta-analysis of RNFL thickness between patients and healthy controls
A: Superior RNFL thickness; B: Nasal RNFL thickness; C: Inferior RNFL thickness; D: Temporal RNFL thickness.
Figure 3
Figure 3. Meta-analysis of subgroup between patients with only one eye and both eyes per subject.
See this image and copyright information in PMC

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