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. 2012 Nov;31(11):3207-9.
doi: 10.1007/s10096-012-1686-7. Epub 2012 Jul 10.

Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations

W van der Hoek  1 , C C H Wielders, B Schimmer, M C A Wegdam-Blans, J Meekelenkamp, H L Zaaijer, P M Schneeberger
Affiliations

Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations

W van der Hoek et al. Eur J Clin Microbiol Infect Dis. 2012 Nov.

Abstract

The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (≥1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes.

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