doi: 10.1002/anie.201203852.
Epub 2012 Jul 9.
Cooperative assistance in bifunctional organocatalysis: enantioselective Mannich reactions with aliphatic and aromatic imines
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- PMID: 22777736
- DOI: 10.1002/anie.201203852
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Cooperative assistance in bifunctional organocatalysis: enantioselective Mannich reactions with aliphatic and aromatic imines
Angew Chem Int Ed Engl.
.
Abstract
Hold them tight: Guided by X-ray structures, bifunctional thiourea catalysts containing an activating intramolecular hydrogen bond were redesigned. The new catalysts were used to effect a highly enantioselective Mannich reaction between malonates and both aliphatic and aromatic imines (see scheme; Boc=tert-butoxycarbonyl).
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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