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. 1990 Nov;9(11):1327-37.
doi: 10.1002/sim.4780091110.

Quantifying misclassification bias in cohort studies of vaccine efficacy

C P Farrington  1
Affiliations

Quantifying misclassification bias in cohort studies of vaccine efficacy

C P Farrington. Stat Med. 1990 Nov.

Abstract

A simple mathematical model is presented to quantify the bias due to misclassification in prospective cohort studies of vaccine efficacy. Limitations of methods based on quantifying misclassification in 2 x 2 tables are discussed. The model is applied to data from three examples of the design and analysis of studies of pertussis vaccine efficacy.

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