Review
doi: 10.1021/cn1000588.
ACS chemical neuroscience molecule spotlight on dimebon
Affiliations
- PMID: 22778847
- PMCID: PMC3368692
- DOI: 10.1021/cn1000588
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Review
ACS chemical neuroscience molecule spotlight on dimebon
ACS Chem Neurosci.
.
Abstract
Dimebon (latrepirdine) is an antihistamine drug that has been used clinically in Russia since the early 1980s and is being studied jointly by Pfizer and Medivation for patients with Alzheimer's disease. The results from a pivotal Phase 3 clinical trial (CONNECTION) showed that Dimebon (latrepirdine) failed to meet its coprimary or secondary efficacy end points.
Keywords: AD; Alzheimerʼs Disease; Dimebon; Neurodegeneration; clinical trials.
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References
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- Lermontova N. N.; Lukoyanov N. V.; Serkova T. P.; Lukoyanova E. A.; Bachurin S. O. (2000) Dimebon improves learning in animals with experimental Alzheimer’s disease. Bull. Exp. Biol. Med. 129, 544–546. - PubMed
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- Doody R. S.; Gavrilova S. I.; Sano M.; Thomas R. G.; Aisen P. S.; Bachurin S. O.; Hung D. (2008) Effect of dimebon on cognition, activities of daily living, behavior, and global function in patients with mild-to-moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled study. Lancet 327, 207–215. - PubMed
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- Medivation press release, Sep 3, 2008. http://investors.medivation.com/releasedetail.cfm?ReleaseID=331827.
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- Medivation press release, Mar 3, 2010. http://investors.medivation.com/releasedetail.cfm?ReleaseID=448818.
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