Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jun 28;4(6):247-52.
doi: 10.4329/wjr.v4.i6.247.

Ultrasound- and MR-guided focused ultrasound surgery for prostate cancer

Chiara Zini  1 , Elisabeth Hipp, Stephen Thomas, Alessandro Napoli, Carlo Catalano, Aytekin Oto
Affiliations

Ultrasound- and MR-guided focused ultrasound surgery for prostate cancer

Chiara Zini et al. World J Radiol. .

Abstract

Prostate cancer (PC) is one of the most frequently diagnosed cancers in men. There are a number of treatment options for PC with a different therapeutic approach between USA and Europe. Radical prostatectomy is one of the most used therapies but focal gland therapy is an emerging approach, especially for localized tumors. In this scenario, high intensity focused ultrasound (HIFU) has been incorporated in certain medical association guidelines. HIFU has been employed for about 10 years especially for localized PC. Results are promising with a 5-year biochemical survival rate ranging from 45% to 84%. Collateral events are rare and HIFU retreatment is not common. Magnetic resonance guided focused ultrasound surgery (MRgFUS) was recently presented as a method for ablation with focused ultrasound under magnetic resonance imaging guidance. It has the advantage of improved targeting and real time temperature monitoring but only a few studies have been conducted with human patients. The aim of this review is to describe the current status of HIFU and MRgFUS in the therapy of PC.

Keywords: High intensity focused ultrasound; Magnetic resonance guided focused ultrasound surgery; Prostate cancer.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Magnetic resonance guided focused ultrasound surgery suite at the University of Chicago. A: Magnetic resonance guided focused ultrasound surgery (MRgFUS) probe and phase array; B: Focused picture of MRgFUS phased array transducer.
Figure 2
Figure 2
Magnetic resonance guided focused ultrasound surgery of human prostate. A: Pre-sonification scan, catheter is visible in prostate urethra and transrectal probe is present in the rectum, filled by water. Hypointense focus in the left peripheral zone represents patient`s biopsy proven prostate cancer; B, C: Post-contrast T1-weighted images through prostate demonstrates non-enhancing ablation defect in the left peripheral zone.
See this image and copyright information in PMC

References

    1. American Cancer Society. Prostate Cancer Facts. In: Cancer Facts and Figures 2009., editor. Atlanta, GA: American Cancer Society; 2009. pp. 19–20.
    1. European Cancer Observatory. Cancer Fact Sheets. Available from: http://eu-cancer.iarc.fr/2-cancer-fact-sheets.html,en.
    1. Warmuth M, Johansson T, Mad P. Systematic review of the efficacy and safety of high-intensity focussed ultrasound for the primary and salvage treatment of prostate cancer. Eur Urol. 2010;58:803–815. - PubMed
    1. American Urological Association Education and Research, Inc. Guidelines for the management of clinically localized prostate cancer: 2007 update. Available from: http://www.auanet.org/content/clinical-practice-guidelines/clinical-guid....
    1. Heidenreich A, Bolla M, Mason MD, Matveev V, Mottet N, Schmid HP, van der Kwast TH, Wiegel T, Zattoni F. Guidelines on Prostate Cancer. January, 2011. Available from: http://www.uroweb.org/guidelines/online-guidelines/ - PubMed