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. 2012:2012:263871.
doi: 10.5402/2012/263871. Epub 2012 Jun 18.

PP13 and PAPP-A in the First and Second Trimesters: Predictive Factors for Preeclampsia?

Narges Moslemi Zadeh  1 , Farshad Naghshvar, Sepideh Peyvandi, Parand Gheshlaghi, Sara Ehetshami
Affiliations

PP13 and PAPP-A in the First and Second Trimesters: Predictive Factors for Preeclampsia?

Narges Moslemi Zadeh et al. ISRN Obstet Gynecol. 2012.

Abstract

Background. Preeclampsia affects 5-6% of all pregnancies. Predictive factors of preeclampsia can be helpful in early diagnosis of this disease. In this study the predictive values of biochemical markers placenta protein 13 (PP13) and pregnancy-associated plasma protein A (PAPP-A) have been assessed in early diagnosis of preeclampsia. Methods. This case-control study was conducted on 1500 women who presented to a healthcare center of Sari, Iran, between 2010 and 2011. Blood samples were drawn in weeks 11-13 and 24-28 of pregnancy. Of them who developed preeclampsia were considered as case group. A control group consisted of similar women regarding mean age, body mass index (BMI), and pregnancy age. PAPP-A and PP13 serum levels were measured. Data were analyzed using proper statistical tests. Results. PAPP-A and PP13 serum levels were significantly lower in both the first and second trimesters in women who developed preeclampsia (P < 0.001). The cumulative value of all four variables with cut-off point of 238.5 has sensitivity, specificity of 91.0%, and undercurve surface of 0.968 which is the most diagnostic value for preeclampsia. Conclusion. It is possible to advantage measuring of PAPP-A and PP13 in the first and second trimesters especially their cumulative values in both trimesters for prediction of the incidence of preeclampsia.

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Figure 1
Frequency of mild and severe preeclampsia.
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