Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Jul;32(4):298-303.
doi: 10.3343/alm.2012.32.4.298. Epub 2012 Jun 20.

Lung infection caused by Mycobacterium riyadhense confused with Mycobacterium tuberculosis: the first case in Korea

Jung-In Choi  1 , Ji-Hun Lim, Sung-Ryul Kim, Seon Ho Lee, Jae-Sun Park, Kwang Won Seo, Jae Bum Jeon, Joseph Jeong
Affiliations
Case Reports

Lung infection caused by Mycobacterium riyadhense confused with Mycobacterium tuberculosis: the first case in Korea

Jung-In Choi et al. Ann Lab Med. 2012 Jul.

Abstract

A slowly growing, non-chromogenic mycobacterial strain was isolated from sputum and bronchial lavage fluid samples of a patient presenting with productive cough, blood-tinged sputum, low-grade fever, and weakness. A positive acid-fast bacilli sputum smear result prompted the initiation of an anti-tuberculosis regimen. Multiplex real-time PCR showed a negative result for Mycobacterium tuberculosis complex and a positive result for nontuberculous mycobacteria. The DNA chip test confirmed this organism as a member of the genus Mycobacterium, but could not specify the species. Interestingly, the mycolic acid patterns obtained by HPLC nearly overlapped with those of M. simulans. The sequences of the Mycobacterium 16S rRNA gene and 16S-23S internal transcribed spacer region were unique and were found to have 100% similarity with those of M. riyadhense. After a review of the literature, we report this case as the first Korean case of M. riyadhense lung infection.

Keywords: Mycobacterium; Mycobacterium riyadhense; Mycobacterium simulans; Nontuberculous mycobacteria.

PubMed Disclaimer

Conflict of interest statement

No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
HPLC pattern of strain UUH-10070721646 (right) compared with that of Mycobacterium tuberculosis (left); the HPLC pattern of UUH-10070721646 is characterized by a single, late cluster of peaks.
Fig. 2
Fig. 2
Phylogenetic relationships of strain UUH-10070721646 and related Mycobacterium species on the basis of 16S rRNA gene sequences.
See this image and copyright information in PMC

References

    1. Tortoli E. The new mycobacteria: an update. FEMS Immunol Med Microbiol. 2006;48:159–178. - PubMed
    1. McNabb A, Eisler D, Adie K, Amos M, Rodrigues M, Stephens G, et al. Assessment of partial sequencing of the 65-kilodalton heat shock protein gene (hsp65) for routine identification of Mycobacterium species isolated from clinical sources. J Clin Microbiol. 2004;42:3000–3011. - PMC - PubMed
    1. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of non-tuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367–416. - PubMed
    1. Subcommittee of the Joint Tuberculosis Committee of the British Thoracic Society. Management of opportunist mycobacterial infections: Joint Tuberculosis Committee Guidelines 1999. Thorax. 2000;55:210–218. - PMC - PubMed
    1. Forbes BA, Sahm DF, et al., editors. Bailey and Scott's Diagnostic Microbiology. 12th ed. St. Louis: Mosby Elsevier; 2007. p. 481.

Publication types

MeSH terms