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Randomized Controlled Trial
. 2013 Sep-Oct;16(5):401-6; discussion 406.
doi: 10.1111/j.1525-1403.2012.00483.x. Epub 2012 Jul 10.

Safety in the use of dexmedetomidine (precedex) for deep brain stimulation surgery: our experience in 23 randomized patients

Marco Sassi  1 , Edvin Zekaj, Alessandra Grotta, Alberto Pollini, Armando Pellanda, Massimo Borroni, Claudio Pacchetti, Claudia Menghetti, Mauro Porta, Domenico Servello
Affiliations
Randomized Controlled Trial

Safety in the use of dexmedetomidine (precedex) for deep brain stimulation surgery: our experience in 23 randomized patients

Marco Sassi et al. Neuromodulation. 2013 Sep-Oct.

Abstract

Objective: Evaluation of safety and efficacy of dexmedetomidine in deep brain stimulation (DBS) surgery.

Materials and methods: A cohort of 23 patients, candidates for DBS for Parkinson's disease, Tourette syndrome, or obsessive-compulsive disorder, was randomized in two groups: dexmedetomidine group and control group. Standard anesthesiologic parameters were recorded and analyzed, together with the need for other medications. A ten-degree scale (visual analog scale) assessing patient discomfort during DBS also was recorded at the end of surgery.

Results: The results demonstrated good stability of intraoperative monitoring: no respiratory depression and good overall cooperation with the neurologist, while no side-effects were recorded.

Conclusions: Our conclusion is that dexmedetomidine should be considered as a valuable option for sedation in poorly collaborating patients undergoing DBS surgery.

Keywords: anesthesiology; deep brain stimulation; dexmedetomidine; safety; sedation.

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