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Clinical Trial
. 2012 Dec;28(12):965-8.
doi: 10.3109/09513590.2012.696753. Epub 2012 Jul 11.

Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome

Lubna Pal  1 , Amber Berry, Luisa Coraluzzi, Erin Kustan, Cheryl Danton, Julia Shaw, Hugh Taylor
Affiliations
Clinical Trial

Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome

Lubna Pal et al. Gynecol Endocrinol. 2012 Dec.

Abstract

Objective: To assess effects of vitamin D and Calcium (Ca) on hormonal and metabolic milieu of polycystic ovary syndrome (PCOS).

Design: Single arm open label trial.

Methods: Twelve overweight and vitamin D deficient women with PCOS underwent a 2 hour oral glucose tolerance testing at baseline and following 3-month supplementation with vitamin D (daily dose of 3533 IU, increased to 8533 IU after the first five participants) and 530 mg elemental Ca daily.

Main outcome measures: Blood pressure (BP), plasma glucose, insulin, total testosterone (T) androstenedione (A), sex hormone binding globulin, lifestyle parameters were assessed at baseline and following 3-month intervention. Insulin resistance (IR) and area under the curve for glucose and insulin were computed; paired analyses were conducted.

Results: Improved serum 25OHD (p < 0.001) and reductions in total T (p = 0.036) and A (p = 0.090) levels were noted following 3-month supplementation, compared to baseline. Significant lowering in BP parameters was seen in participants with baseline BP ≥ 120/80 mmHg (n = 8) and in those with baseline serum 25OHD ≤20 ng/ml (n = 9). Parameters of glucose homeostasis and IR remained unchanged (p > 0.05).

Conclusions: Androgen and BP profiles improved followed three month intervention, suggesting therapeutic implications of vitamin D and Ca in overweight and vitamin D deficient women with PCOS.

Trial registration: ClinicalTrials.gov NCT00743574.

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Conflict of interest statement

Disclosure statement: The authors have no conflicts to disclose

Declaration of Interest: This research was made possible by CTSA Grant Number UL1 RR024139 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH.

Figures

Figure 1
Figure 1
Flow diagram outlines enrollment details for the clinical trial, registration number NCT00743574, (clinicaltrials.gov).
See this image and copyright information in PMC

References

    1. Carmina E, Lobo RA. Polycystic ovary syndrome (PCOS) arguably the most common endocrinopathy is associated with significant morbidity in women. J Clin Endocrinol Metab. 1999;84:1897–1899. - PubMed
    1. Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care. 1999;22:141–6. - PubMed
    1. Lakhani K, Constantinovici N, Purcell WM, Fernando R, Hardiman P. Internal carotid artery haemodynamics in women with polycystic ovaries. Clin Sci (Lond) 2000;98:661–5. - PubMed
    1. Shroff R, Kirschner A, Maifeld M, Van Beek EJ, Jagasia D, Dokras A. Young Obese Women with Polycystic Ovary Syndrome have Evidence of Early Coronary Atherosclerosis. J Clin Endocrinol Metab. 2007;92:4609–14. - PubMed
    1. Thys-Jacobs S, Donovan D, Papadopoulos A, Sarrel P, Bilezikian JP. Vitamin and calcium dysregulation in the polycystic ovarian syndrome. Steroids. 1999;64:430–435. - PubMed

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