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Review
. 1990 Nov;15(11):425-30.
doi: 10.1016/0968-0004(90)90280-o.

The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

T L Blundell  1 , R Lapatto, A F Wilderspin, A M Hemmings, P M Hobart, D E Danley, P J Whittle
Affiliations
Review

The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

T L Blundell et al. Trends Biochem Sci. 1990 Nov.

Abstract

A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.

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