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Review
. 2013 Jul-Aug;34(4):875-82.
doi: 10.1016/j.mam.2012.06.011. Epub 2012 Jul 7.

Epigenetic mechanisms governing the process of neurodegeneration

Irfan A Qureshi  1 , Mark F Mehler
Affiliations
Review

Epigenetic mechanisms governing the process of neurodegeneration

Irfan A Qureshi et al. Mol Aspects Med. 2013 Jul-Aug.

Abstract

Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.

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References

    1. Moving AHEAD with an international human epigenome project. Nature. 2008;454(7205):711–715. - PMC - PubMed
    1. A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet. 2011;7(6):e1002142. - PMC - PubMed
    1. Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M. Epigenetic protein families: a new frontier for drug discovery. Nat. Rev. Drug Discov. 2012;11(5):384–400. - PubMed
    1. Auclair G, Weber M. Mechanisms of DNA methylation and demethylation in mammals. Biochimie. 2012 - PubMed
    1. Bader AG, Brown D, Winkler M. The promise of microRNA replacement therapy. Cancer Res. 2010;70(18):7027–7030. - PMC - PubMed

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