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. 2012 Jun 14:3:211.
doi: 10.3389/fphys.2012.00211. eCollection 2012.

Cardiac conduction system anomalies and sudden cardiac death: insights from murine models

Amelia Aránega  1 , Angel J De La Rosa, Diego Franco
Affiliations

Cardiac conduction system anomalies and sudden cardiac death: insights from murine models

Amelia Aránega et al. Front Physiol. .

Abstract

The cardiac conduction system (CCS) is composed of a group of myocardial tissues that control and coordinate the heart. Alterations in the CCS - especially in the His-Purkinje system, have been identified as a major cause of lethal arrhythmias. Unstable arrhythmias secondary to channelopathies significantly increase the risk of sudden cardiac death (SCD). SCD is a major contributor to mortality in industrialized countries, and most cases of SCD in the young are related to inherited ion channel diseases. In this paper, we review a series of studies with murine transgenic models that revealed that some arrhythmias are associated with the CCS and may lead to SCD.

Keywords: cardiac conduction system; ion channel; sudden death.

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