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. 2012 Jul 6:3:186.
doi: 10.3389/fimmu.2012.00186. eCollection 2012.

How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer

Inbal Daniel-Meshulam  1 , Shlomo Ya'akobi, Chen Ankri, Cyrille J Cohen
Affiliations

How (specific) would like your T-cells today? Generating T-cell therapeutic function through TCR-gene transfer

Inbal Daniel-Meshulam et al. Front Immunol. .

Abstract

T-cells are central players in the immune response against both pathogens and cancer. Their specificity is solely dictated by the T-cell receptor (TCR) they clonally express. As such, the genetic modification of T lymphocytes using pathogen- or cancer-specific TCRs represents an appealing strategy to generate a desired immune response from peripheral blood lymphocytes. Moreover, notable objective clinical responses were observed in terminally ill cancer patients treated with TCR-gene modified cells in several clinical trials conducted recently. Nevertheless, several key aspects of this approach are the object of intensive research aimed at improving the reliability and efficacy of this strategy. Herein, we will survey recent studies in the field of TCR-gene transfer dealing with the improvement of this approach and its application for the treatment of malignant, autoimmune, and infectious diseases.

Keywords: T-cell receptor; T-cells; TCR-gene transfer; autoimmunity; cancer; immunotherapy; infectious diseases.

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Figures

FIGURE 1
FIGURE 1
A summary of optimization strategies for TCR expression and pairing. The naturally expressed/endogenous TCR is depicted in gray and the introduced/exogenous TCR in blue/purple. TM, transmembrane; sc, single chain.
See this image and copyright information in PMC

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