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Review
. 2012 Jun;12(3):276-80.
doi: 10.7861/clinmedicine.12-3-276.

Sepsis: recognition and treatment

J Soong  1 , N Soni
Affiliations
Review

Sepsis: recognition and treatment

J Soong et al. Clin Med (Lond). 2012 Jun.
No abstract available

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Figures

Fig 1.
Fig 1.
Fig 2.
Fig 2.
Concepts in sepsis: inflammation and response to various danger signals. PAMPs = pathogen-associated molecular patterns; DAMPs = damage-associated molecular patterns; LPS = lipopolysaccharide; LTA = lipotechoic acid; AGE = advanced glycation end products; ATP = adenosine triphosphate; HMGB1 = high-mobility group box 1; HSP = heat shock proteins; TLR = toll-like receptor; NLR = NOD-like receptor; RAGE = receptor for advanced glycation endproducts; PRRs = pattern recognition receptor; NF-κB = nuclear factor kappa-light-chain-enhancer of activated B cells; iNOS = inducible nitric oxide synthase; COX 2 = cyclooxygenase-2.
Fig 3.
Fig 3.
Concepts in sepsis: systemic inflammatory response syndrome (SIRS), compensatory anti-inflammatory response syndrome (CARS) and mixed antagonist response syndrome (MARS) (adapted from Ref 3).
See this image and copyright information in PMC

References

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    1. Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. Review. J Leukoc Biol 2007;81:1–5 - PubMed
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    1. Kellum JA, Kong L, Fink MP, et al. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007;167:1655–6310.1001/archinte.167.15.1655 - DOI - PMC - PubMed
    1. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303–1010.1097/00003246-200107000-00002 - DOI - PubMed

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