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Review
. 2012 Oct:27 Suppl 3:iii43-50.
doi: 10.1093/ndt/gfs283. Epub 2012 Jul 10.

From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD

Marco Prunotto  1 , David C Budd, Matthias Meier, Ivan Formentini, Guido Hartmann, Silvia Pomposiello, Solange Moll
Affiliations
Review

From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD

Marco Prunotto et al. Nephrol Dial Transplant. 2012 Oct.

Abstract

Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD.

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