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. 1990 Aug;323(8):501-5.
doi: 10.1002/ardp.19903230811.

Inotropic activities of imidazopyridines

P Barraclough  1 , J W Black, D Cambridge, V P Gerskowitch, R A Hull, R Lyer, W R King, C O Kneen, M S Nobbs, G P Shah, et al.
Affiliations

Inotropic activities of imidazopyridines

P Barraclough et al. Arch Pharm (Weinheim). 1990 Aug.

Abstract

A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed.

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