Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Aug;323(8):507-12.
doi: 10.1002/ardp.19903230812.

Cardiotonic 'C' ring modified isomazole analogues

P Barraclough  1 , J W Black, D Cambridge, D A Demaine, V P Gerskowitch, H Giles, A P Hill, R A Hull, R Lyer, W R King, et al.
Affiliations

Cardiotonic 'C' ring modified isomazole analogues

P Barraclough et al. Arch Pharm (Weinheim). 1990 Aug.

Abstract

Isomazole analogues which have achiral electron withdrawing substituents at the 4'-position and analogues with heterocyclic 'C' rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the 'C' ring without loss of activity. The 4'-methylsulphonyl, -cyano, -carboxamido, and acetyl analogues had similar inotropic potencies to Isomazole whilst displaying superior cardiovascular profiles in in vivo studies.

PubMed Disclaimer

LinkOut - more resources