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. 2012 Jul 11;17(7):8419-29.
doi: 10.3390/molecules17078419.

Evaluation of antioxidant and immunity-enhancing activities of Sargassum pallidum aqueous extract in gastric cancer rats

Rui-Li Zhang  1 , Wen-Da Luo, Tie-Nan Bi, Shen-Kang Zhou
Affiliations

Evaluation of antioxidant and immunity-enhancing activities of Sargassum pallidum aqueous extract in gastric cancer rats

Rui-Li Zhang et al. Molecules. .

Abstract

The effect of Sargassum pallidum (brown seaweed) aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with Sargassum pallidum aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against N-methyl-N′-nitro-Nnitrosoguanidine (MNNG)-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10) levels, decreasing interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that Sargassum pallidum aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats.

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Figures

Figure 1
Figure 1
(A). Effect of Sargassum pallidum aqueous extract on serum IL-2, (B) IL-4 and (C) IL-10 levels in different groups.
Figure 2
Figure 2
(A) Effect of Sargassum pallidum aqueous extract on serum IL-6, (B) IL-1β and (C) TNF-α levels in different groups.
Figure 3
Figure 3
Effect of Sargassum pallidum aqueous extract on serum and gastric mucosa MDA level in different groups.
Figure 4
Figure 4
Effect of Sargassum pallidum aqueous extract on serum and gastric mucosa GSH level in different groups.
Figure 5
Figure 5
Effect of Sargassum pallidum aqueous extract on serum and gastric mucosa SOD, CAT and GSH-Px in different groups.
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