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Case Reports
. 2012 Aug;37(8):807-9.
doi: 10.1097/RLU.0b013e318251e1d3.

Amyloid imaging mismatch

Ryogo Minamimoto  1 , Kenji Ishii, Kazuo Kubota, Miyako Morooka, Momoko Okasaki, Kimiteru Ito, Takuya Mitsumoto, Kazuhiko Nakajima, Takashi Sato, Makoto Mochizuki, Osamu Okazaki
Affiliations
Case Reports

Amyloid imaging mismatch

Ryogo Minamimoto et al. Clin Nucl Med. 2012 Aug.

Abstract

An 82-year-old man with suspected systemic amyloidosis and complete atrioventricular block underwent vascular biopsy during his pacemaker implantation with pathology showing amyloid deposits. 99mTc-aprotinin SPECT revealed increased radiotracer uptake along the left ventricular wall, consistent with cardiac amyloidosis. 11C-PiB PET/CT performed for the evaluation of amyloid deposits in the brain showed findings suggestive of Alzheimer disease without abnormal radiotracer concentration in the myocardium to match the 99mTc-aprotinin SPECT findings. Dynamic PET images showed increased 11C-PiB concentration in the left ventricular myocardium at 2 minutes after injection, with subsequent tracer clearance by approximately 5 minutes, consistent with normal 11C-PiB biodistribution.

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