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Review
. 2012 Jul;191(3):671-702.
doi: 10.1534/genetics.111.137265.

RNA degradation in Saccharomyces cerevisae

Roy Parker  1
Affiliations
Review

RNA degradation in Saccharomyces cerevisae

Roy Parker. Genetics. 2012 Jul.

Abstract

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs, and noncoding RNAs. In addition, numerous quality control mechanisms that target aberrant RNAs have been identified. Generally, each decay mechanism contains factors that funnel RNA substrates to abundant exo- and/or endonucleases. Key issues for future work include determining the mechanisms that control the specificity of RNA degradation and how RNA degradation processes interact with translation, RNA transport, and other cellular processes.

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Figures

Figure 1
Figure 1
(A) General mRNA decay pathways. (B) Specialized mRNA decay pathways.
Figure 2
Figure 2
Model for mRNA decapping.
Figure 3
Figure 3
Model for the nonsense-mediated decay.
Figure 4
Figure 4
Model for no-go decay.
Figure 5
Figure 5
Model for non-stop decay.
Figure 6
Figure 6
Mechanisms of degradation for unspliced pre-mRNAs.
See this image and copyright information in PMC

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References

    1. Aebi M., Kirchner G., Chen J. Y., Vijayraghavan U., Jacobson A., et al. , 1990. Isolation of a temperature-sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 265: 16216–16220 - PubMed
    1. Alexandrov A., Chernyakov I., Gu W., Hiley S. L., Hughes T. R., et al. , 2006. Rapid tRNA decay can result from lack of nonessential modifications. Mol. Cell 21: 87–96 - PubMed
    1. Allmang C., Petfalski E., Podtelejnikov A., Mann M., Tollervey D., et al. , 1999. The yeast exosome and human PM-Scl are related complexes of 3′ → 5′ exonucleases. Genes Dev. 13: 2148–2158 - PMC - PubMed
    1. Allmang C., Mitchell P., Petfalski E., Tollervey D., 2000. Degradation of ribosomal RNA precursors by the exosome. Nucleic Acids Res. 28: 1684–1691 - PMC - PubMed
    1. Amrani N., Ganesan R., Kervestin S., Mangus D. A., Ghosh S., et al. , 2004. A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature 432: 112–118 - PubMed