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. 2012 Mar;22(2):88-93.
doi: 10.4103/0971-4065.97110.

Is there any correlation between hypercalciuria and nocturnal enuresis?

A Nikibakhsh  1 , H Poostindooz, H Mahmoodzadeh, M Karamyyar, R Rasoul Ghareaghaji, N Sepehrvand
Affiliations

Is there any correlation between hypercalciuria and nocturnal enuresis?

A Nikibakhsh et al. Indian J Nephrol. 2012 Mar.

Abstract

Nocturnal enuresis is a common problem among children. Hypercalciuria has been proposed as an important etiology of bedwetting. We investigated the incidence of hypercalciuria among children with nocturnal enuresis and age- and sex-matched healthy controls. In this case-control study 118 children with nocturnal enuresis and 100 age-, sex-, and educational district-matched healthy controls were recruited. Urine samples were obtained from each subject twice: immediately after awakening and 2 hours later at school. Urinary calcium and creatinine levels were measured and the subjects with a urinary calcium/creatinine ratio more than 0.2 were considered as hypercalciuric. Serum Ca, P, Na, K, and PTH levels were measured for all hypercalciuric subjects. The mean urine calcium to creatinine ratio in the second urine sample was 0.070±0.06 mg/mg and 0.050±0.046, respectively in the case and control groups (P=0.008). There were 12/118 and 3/100 hypercalciuric subjects in the case and control groups respectively (P=0.032). The serum Ca, P, Na, K, and PTH levels were in normal range in all hypercalciuric subjects. In our study there was a significant difference in the frequency of hypercalciuria among children with nocturnal enuresis and healthy controls, so we can suggest adding the measurement of urine electrolytes especially the calcium level in patients with nocturnal enuresis.

Keywords: Children; hypercalciuria; nocturnal enuresis.

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Conflict of interest statement

Conflict of Interest: The authors declared that there was no conflict of interests. The results presented in this paper have not been published previously in whole or part, except in abstract format.

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References

    1. Nevéus T, von Gontard A, Hoebeke P, Hjälmås K, Bauer S, Bower W, et al. The standardization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children's Continence Society. J Urol. 2006;176:314–24. - PubMed
    1. Pace G, Aceto G, Cormio L, Traficante A, Tempesta A, Lospalluti ML, et al. Nocturnal enuresis can be caused by absorptive hypercalciuria. Scand J Urol Nephrol. 1999;33:111–4. - PubMed
    1. Nevéus T, Hansell P, Stenberg A. Vasopressin and hypercalciuria in enuresis: a reappraisal. BJU Int. 2002;90:725–9. - PubMed
    1. Valenti G, Laera A, Pace G, Aceto G, Lospalluti ML, Penza R, et al. Urinary aquaporin 2 and calciuria correlate with the severity of enuresis in children. J Am Soc Nephrol. 2000;11:1873–81. - PubMed
    1. De Guchtenaere A, Vande Walle C, Van Sintjan P, Raes A, Donckerwolcke R, Van Laecke E, et al. Nocturnal polyuria is related to absent circadian rhythm of glomerular filtration rate. J Urol. 2007;178:2626–9. - PubMed