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. 2012 Jul 10;3(7):111-5.
doi: 10.5306/wjco.v3.i7.111.

Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies

Giovannella Palmieri  1 , Carlo Buonerba, Piera Federico, Luigi Formisano, Lucia Nappi, Giuseppe Di Lorenzo, Mirella Marino, Vincenzo Damiano
Affiliations

Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies

Giovannella Palmieri et al. World J Clin Oncol. .

Abstract

Although thymic epithelial tumors (TETs) are rare in the general population, they represent the most frequently diagnosed primary malignant tumor of the anterior mediastinum. Unlike localized disease, metastatic disease is invariably fatal. While several chemotherapy agents have proven to be effective in TETs, somatostatin analogs are the only targeted agents with an established role in this disease. Everolimus is an mTOR inhibitor with multiple application in oncology. In this report, we show for the first time that everolimus was effective in two heavily pretreated patients with advanced TETs, with a progression-free survival longer than 1 year and minimal toxicity.

Keywords: Everolimus; Mediastinum; Target; Thymoma; mTOR.

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Figures

Figure 1
Figure 1
The marked decrease in fluoro-2-deoxy-D-glucose uptake in positron emission tomography/computed tomography performed in October, 2010 (below) in comparison to positron emission tomography/computed tomography performed in August, 2010 (above) in patient 1. Color scales are approximately the same.
See this image and copyright information in PMC

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