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Review

Computer Modeling of Epilepsy

Marianne J Case  1 , Robert J Morgan  1 , Calvin J Schneider  1 , Ivan Soltesz  1
Jeffrey L Noebels, Massimo Avoli, Michael A Rogawski, Richard W Olsen, Antonio V Delgado-Escueta
, editors.
In: Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.
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Review

Computer Modeling of Epilepsy

Marianne J Case et al.
Free Books & Documents

Excerpt

This chapter reviews current computational models and proposes future directions for computer modeling in the field of epilepsy. We consider the potential therapeutic applications of modeling in the both the treatment and prevention of epilepsy. Additionally, we discuss the benefits of computer modeling for research. The models discussed include single cells with mutated ion channels, mean-field network and detailed network models. We conclude by suggesting some excellent resources for those interested in learning more about computer modeling in neuroscience and epilepsy.

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References

    1. World Health Organization. Epilepsy, Epilepsy Fact Sheet. [Accessed August, 2010]. http://www.who.int/mediacentre/factsheets/fs999/en/index.html .
    1. Jobst BC, Darcey TM, Thadani VM, Roberts DW. Brain stimulation for the treatment of epilepsy. Epilepsia. 2010;51:88–92. - PubMed
    1. Glasscock E, Qian J, Yoo JW, Noebels JL. Masking epilepsy by combining two epilepsy genes. Nat Neurosci. 2007;10(12):1554–1558. - PubMed
    1. Hines M, Markram H, Schürmann F. Fully implicit parallel simulation of single neurons. Journal of Computational Neuroscience. 2008;25(3):439–448. - PMC - PubMed
    1. Markram H. The Blue Brain Project. Nat Rev Neurosci. 2006;7(2):153–160. - PubMed

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