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Comment
. 2012 Jul 10;22(1):5-6.
doi: 10.1016/j.ccr.2012.06.006.

To the rescue: the Fanconi anemia genome stability pathway salvages replication forks

George-Lucian Moldovan  1 , Alan D D'Andrea
Affiliations
Comment

To the rescue: the Fanconi anemia genome stability pathway salvages replication forks

George-Lucian Moldovan et al. Cancer Cell. .

Abstract

DNA damage can arrest replication forks during S phase. Failure to stabilize and restart arrested forks results in fork collapse and genomic instability. In this issue of Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways cooperate to protect stalled replication forks from degradation.

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Figures

Figure 1
Figure 1. The Fanconi Anemia pathway and BRCA2 cooperate to promote the stability of stalled replication forks
(A) FA proteins and BRCA2 protect stalled replication forks against degradation by stabilizing RAD51 filaments. (B) In the absence of the FA/BRCA pathway, the MRE11 nuclease degrades stalled replication forks, promoting genomic instability. (C) Fork protection in FA/BRCA pathway mutants can be rescued by stabilizing RAD51 filaments. RAD51 is represented by red dots.
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