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. 2013 Mar;41(3):635-43.
doi: 10.1183/09031936.00030612. Epub 2012 Jul 12.

Tuberculosis treatment outcome monitoring in European Union countries: systematic review

Rob van Hest  1 , Csaba Ködmön, Suzanne Verver, Connie G M Erkens, Masja Straetemans, Davide Manissero, Gerard de Vries
Affiliations
Free PMC article

Tuberculosis treatment outcome monitoring in European Union countries: systematic review

Rob van Hest et al. Eur Respir J. 2013 Mar.
Free PMC article

Abstract

Treatment success measured by treatment outcome monitoring (TOM) is a key programmatic output of tuberculosis (TB) control programmes. We performed a systematic literature review on national-level TOM in the 30 European Union (EU)/European Economic Areas (EEA) countries to summarise methods used to collect and report data on TOM. Online reference bibliographic databases PubMed/MEDLINE and EMBASE were searched to identify relevant indexed and non-indexed literature published between January 2000 and August 2010. The search strategy resulted in 615 potentially relevant indexed citations, of which 27 full-text national studies (79 data sets) were included for final analysis. The selected studies were performed in 10 EU/EEA countries and gave a fragmented impression of TOM in the EU/EEA. Publication year, study period, sample size, databases, definitions, variables, patient and outcome categories, and population subgroups varied widely, portraying a very heterogeneous picture. This review confirmed previous reports of considerable heterogeneity in publications of TOM results across EU/EEA countries. PubMed/MEDLINE and EMBASE indexed studies are not a suitable instrument to measure representative TOM results for the 30 EU/EEA countries. Uniform and complete reporting to the centralised European Surveillance System will produce the most timely and reliable results of TB treatment outcomes in the EU/EEA.

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Conflict of interest statement

Statement of Interest

None declared.

Figures

Figure 1–
Figure 1–
The selection process of articles included in the systematic review. EU: European Union; TOM: treatment outcome monitoring; EEA: European Economic Area.
See this image and copyright information in PMC

References

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