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. 2012 Nov;157(11):2219-22.
doi: 10.1007/s00705-012-1396-6. Epub 2012 Jul 13.

Co-detection in the pathogenesis of severe hand-foot-mouth disease

Li-Juan Liu  1 , Hong-Mei Xu, Xiu-Jun Li, Jun Wang, Xian-Jun Wang, Shu-Jun Ding, Fang Tang, Jing Wang, Ying-Jie Zhang
Affiliations

Co-detection in the pathogenesis of severe hand-foot-mouth disease

Li-Juan Liu et al. Arch Virol. 2012 Nov.

Abstract

It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.

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References

    1. Wang SM, Liu CC, Tseng HW, et al. Clinical spectrum of enterovirus 71 infection of children in southern Taiwan, with an emphasis on the neurological complications. Clin Infect Dis. 1999;29:184–190. doi: 10.1086/520149. - DOI - PubMed
    1. Liu CC, Tseng HW, Wang SM, et al. An outbreak of enterovirus 71 infection in Taiwan, 1998: epidemiologic and clinical manifestations. J Clin Virol. 2000;17:23–30. doi: 10.1016/S1386-6532(00)00068-8. - DOI - PubMed
    1. Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, Yeh TF (1999) Neurologic complications in children with enterovirus 71 infection. N Engl J Med 341:936–942 - PubMed
    1. Ooi MH, Wong SC, Podin Y, et al. Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin Infect Dis. 2007;44:646–656. doi: 10.1086/511073. - DOI - PubMed
    1. Pérez-Vélez CM, Anderson MS, Robinson CC, et al. Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge. Clin Infect Dis. 2007;45:950–957. doi: 10.1086/521895. - DOI - PubMed

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