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Comment
. 2012 Aug;82(3):253-5.
doi: 10.1038/ki.2012.149.

Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation

Miguel G Salom  1 , Bárbara Bonacasa
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Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation

Miguel G Salom et al. Kidney Int. 2012 Aug.
Free article

Abstract

Heme oxygenase-1 (HO-1) is a ubiquitous inducible stress-response enzyme that plays a central role in tissue homeostasis, in protection against oxidative stress, and in the pathogenesis of disease. Kim et al. report a novel transgenic mouse that lacks the endogenous HO-1 gene but contains the human HO-1 gene with all its regulatory elements. These transgenic animals overexpress HO-1 in basal conditions but maintain HO-1 inducibility, protecting the kidney against glycerol- and cisplatin-induced nephrotoxicity.

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