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Comment
. 2012 Aug;82(3):255-6.
doi: 10.1038/ki.2012.127.

Podocyte ACE2 protects against diabetic nephropathy

Raymond C Harris  1
Affiliations
Comment

Podocyte ACE2 protects against diabetic nephropathy

Raymond C Harris. Kidney Int. 2012 Aug.

Abstract

As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzyme 2 (ACE2), which can decrease angiotensin II levels by generation of angiotensin-(1-7). Nadarajah et al. now show that increased podocyte ACE2 activity can attenuate the development of diabetic nephropathy.

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Figures

Figure 1
Figure 1
The podocyte renin–angiotensin system and the mechanisms by which increased ACE2 expression can decrease local angiotensin II production. ACE2, angiotensin-converting enzyme 2; Ang-1-7, angiotensin-(1-7); Ang-1-9, angiotensin-(1-9); AT1, angiotensin II type 1 receptor; GBM, glomerular basement membrane.
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Comment on

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