[Progress in relationship between heritable hypercoagulable state and avascular necrosis of femoral head]
- PMID: 22792766
[Progress in relationship between heritable hypercoagulable state and avascular necrosis of femoral head]
Abstract
Objective: To review the relationship between heritable hypercoagulable state (HHCS) and avascular necrosis of femoral head (ANFH).
Methods: The latest original articles about the relationship between HHCS and ANFH were extensively reviewed.
Results: Several genetic mutations which could cause HHCS, such as thrombophilic factor V G1691A gene, thrombophilic factor II G20210A gene, 5, 10-methylenetetrahydrofolate reductase C677T gene, plasminogen activator inhibitor 1 4G/5G, and tissue factor pathway inhibitor gene, may be genetic risks of ANFH.
Conclusion: HHCS may be a genetic cause of ANFH. Further studies are needed to confirm the relationship between HHCS and Chinese ANFH.
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