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Randomized Controlled Trial
. 2012 Sep-Oct;34(5):439-49.
doi: 10.1016/j.genhosppsych.2012.06.002. Epub 2012 Jul 12.

Motivational enhancement therapy coupled with cognitive behavioral therapy versus brief advice: a randomized trial for treatment of hazardous substance use in pregnancy and after delivery

Kimberly A Yonkers  1 , Ariadna Forray, Heather B Howell, Nathan Gotman, Trace Kershaw, Bruce J Rounsaville, Kathleen M Carroll
Affiliations
Randomized Controlled Trial

Motivational enhancement therapy coupled with cognitive behavioral therapy versus brief advice: a randomized trial for treatment of hazardous substance use in pregnancy and after delivery

Kimberly A Yonkers et al. Gen Hosp Psychiatry. 2012 Sep-Oct.

Abstract

Objective: The objective was to compare the efficacy of motivational enhancement therapy coupled with cognitive behavioral therapy (MET-CBT) to brief advice for treatment of substance use in pregnancy.

Method: This was a randomized, parallel, controlled trial that was yoked to prenatal care and delivered at hospital outpatient clinics. We enrolled 168 substance-using women who had not yet completed an estimated 28 weeks of pregnancy. Obstetrical clinicians provided brief advice, and study nurses administered manualized MET-CBT. The primary outcome was percentage of days in the prior 28 days in which alcohol and/or drugs were used immediately before and 3 months postdelivery.

Results: There were no significant differences across groups in terms of self-reported percentage of days in which drugs or alcohol were used prior to and 3 months postdelivery. Biological measures showed similar results. There was a trend (P=.08) for lower risk of preterm birth among those who received MET-CBT.

Conclusions: The tested interventions had similar therapeutic effects. Hence, both treatments may be suitable for pregnant substance users, depending on the population, setting and provider availability. Interventions that are intensified after delivery may decrease postpartum "rebound" effects in substance misuse.

Trial registration: ClinicalTrials.gov NCT00227903.

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Figures

Figure 1
Figure 1
PRIDE Study Flow Diagram * Randomization occurred between signing consent and the intake visit. Allocation was not disclosed to the participant until after intake was completed and eligibility confirmed
Figure 2
Figure 2
Change in Days of Drug Use and Abstinence Over Time
See this image and copyright information in PMC

References

    1. SAMHSA. Results from the 2007 National Survey on Drug Use and Health: National Findings. Rockville, MD: Office of Applied Studies; 2007. pp. 1–290.
    1. Ebrahim SH, Gfroerer J. Pregnancy-related substance use in the United States during 1996–1998. Obstetrics and Gynecology. 2003;101(2):374–9. - PubMed
    1. Lui S, Terplan M, Smith EJ. Psychosocial interventions for women enrolled in alcohol treatment during pregnancy. Cochrane Database of Systematic Reviews. 2008;(3):CD006753. - PubMed
    1. Terplan M, Lui S. Psychosocial interventions for pregnant women in outpatient illicit drug treatment programs compared to other interventions. Cochrane Database of Systematic Reviews. 2008;(4):CD006037. - PubMed
    1. Jones HE, O’Grady KE, Tuten M. Reinforcement-based treatment improves the maternal treatment and neonatal outcomes of pregnant patients enrolled in comprehensive care treatment. Am J Addictions. 2011;20(3):196–204. - PMC - PubMed

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