Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1990 Dec;150(2):115-8.
doi: 10.1007/BF02072052.

Type 4 renal tubular acidosis (subtype 2) in a patient with methylmalonic acidaemia

T Ohura  1 , M Kikuchi, D Abukawa, H Hanamizu, J Aikawa, K Narisawa, K Tada, H Yunoki
Affiliations
Case Reports

Type 4 renal tubular acidosis (subtype 2) in a patient with methylmalonic acidaemia

T Ohura et al. Eur J Pediatr. 1990 Dec.

Abstract

A 10-month-old male infant with vitamin B12 non-responsive methylmalonic acidaemia is reported. Laboratory results revealed hyperkalaemic, hyperchloraemic, metabolic acidosis with slight azotaemia. The urinary pH decreased (below 5.5) to compensate for acidaemia. Levels of plasma renin activity and plasma aldosterone concentration were low. The renal biopsy showed tubulo-interstitial nephritis. We suggested the diagnosis of type 4 renal tubular acidosis, subtype 2, i.e. hyporeninaemic hypoaldosteronism. We suggest that chronic renal disease may be a common complication of methylmalonic acidaemia.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nihon Naibunpi Gakkai Zasshi. 1979 Sep 20;55(9):1019-37 - PubMed
    1. Can Med Assoc J. 1979 May 19;120(10):1230-5 - PubMed
    1. Tohoku J Exp Med. 1974 Sep;114(1):1-13 - PubMed
    1. Arch Dis Child. 1967 Oct;42(225):492-504 - PubMed
    1. Kidney Int. 1981 Dec;20(6):799-809 - PubMed

Publication types