doi: 10.1016/j.bmc.2012.06.027.
Epub 2012 Jun 21.
New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms
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- PMID: 22795899
- DOI: 10.1016/j.bmc.2012.06.027
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New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms
Bioorg Med Chem.
.
Abstract
New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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