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. 2012 Sep;143(3):e1-e7.
doi: 10.1053/j.gastro.2012.07.011. Epub 2012 Jul 13.

Pathogenesis of liver injury in acute liver failure

Raymond T Chung  1 , R Todd Stravitz  2 , Robert J Fontana  3 , Frank V Schiodt  4 , Wajahat Z Mehal  5 , K Rajender Reddy  6 , William M Lee  7
Affiliations

Pathogenesis of liver injury in acute liver failure

Raymond T Chung et al. Gastroenterology. 2012 Sep.
No abstract available

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Conflict of interest statement

Conflicts of interest

No author received any additional compensation related to this meeting summary. Authors were provided airfare and lodging for the meeting as were all invited attendees via the ALFSG U-01 grant: DK-056389.

Figures

Figure 1
Figure 1
Overview of sterile inflammation. (A) When a cell undergoes an entirely apoptotic mode of death, damage associated molecular patterns (DAMPs) remain sequestered and are not visible to extracellular receptors. With a primary or secondary necrotic cell death DAMPs are released from the dying cell and can engage a variety of receptors on immune cells, resulting in the initiation of a sterile inflammatory response. (B) Inflammasome activation typically requires a priming step that can occur through TLRs and an activation step that can be initiated by a wide range of signals such as adenosine triphosphate, uric acid crystals and reactive oxygen species. Modified with permission from Mehal WZ et al.
See this image and copyright information in PMC

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