Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep;143(3):e1-e7.
doi: 10.1053/j.gastro.2012.07.011. Epub 2012 Jul 13.

Pathogenesis of liver injury in acute liver failure

Raymond T Chung  1 , R Todd Stravitz  2 , Robert J Fontana  3 , Frank V Schiodt  4 , Wajahat Z Mehal  5 , K Rajender Reddy  6 , William M Lee  7
Affiliations

Pathogenesis of liver injury in acute liver failure

Raymond T Chung et al. Gastroenterology. 2012 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

No author received any additional compensation related to this meeting summary. Authors were provided airfare and lodging for the meeting as were all invited attendees via the ALFSG U-01 grant: DK-056389.

Figures

Figure 1
Figure 1
Overview of sterile inflammation. (A) When a cell undergoes an entirely apoptotic mode of death, damage associated molecular patterns (DAMPs) remain sequestered and are not visible to extracellular receptors. With a primary or secondary necrotic cell death DAMPs are released from the dying cell and can engage a variety of receptors on immune cells, resulting in the initiation of a sterile inflammatory response. (B) Inflammasome activation typically requires a priming step that can occur through TLRs and an activation step that can be initiated by a wide range of signals such as adenosine triphosphate, uric acid crystals and reactive oxygen species. Modified with permission from Mehal WZ et al.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Szabo G, Mandrekar P, Dolganiuc A. Innate immune response and hepatic inflammation. Semin Liver Dis. 2007;27:339–350. - PubMed
    1. Shubin NJ, Monaghan SF, Ayala A. Anti-inflammatory mechanisms of sepsis. Contrib Microbiol. 2011;17:108–24. - PubMed
    1. Rutherford AE, Hynan LS, Borges CBS, et al. Serum apoptosis markers in acute liver failure: a pilot study. Clin Gastroenterol Hepatol. 2007;5:1477–83. - PubMed
    1. Win S, Than TA, Han D, et al. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011;286:35071–35078. - PMC - PubMed
    1. Banerjee A, Gerondakis S. Coordinating TLR-activated signaling pathways in cells of the immune system. Immunol Cell Biol. 2007;85:420–424. - PubMed

Publication types

MeSH terms