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Review
. 2013 Sep 10;338(1):23-31.
doi: 10.1016/j.canlet.2012.07.010. Epub 2012 Jul 14.

Medulloblastoma stem cells: modeling tumor heterogeneity

Branavan Manoranjan  1 , Chitra Venugopal, Nicole McFarlane, Bradley W Doble, Sandra E Dunn, Katrin Scheinemann, Sheila K Singh
Affiliations
Review

Medulloblastoma stem cells: modeling tumor heterogeneity

Branavan Manoranjan et al. Cancer Lett. .

Abstract

Brain tumors represent the leading cause of childhood cancer mortality, with medulloblastoma (MB) being the most frequent malignant tumor. In this review we discuss the morphological and molecular heterogeneity of this malignant childhood brain tumor and how this key feature has implicated the presence of a MB stem cell. We focus on evidence from cerebellar development, histopathological and molecular subtypes of MB, the recent identification of brain tumor-initiating cells (BTICs, also referred to as MB stem cells), and the current limitations in studying the interplay between MB stem cells and tumor heterogeneity.

Keywords: Brain-tumor initiating cells; Cancer stem cell; Medulloblastoma; Signaling pathways.

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