[Changes of serum and urinary uric-acid levels after portacaval anastomosis in the rat]
[Article in
German]
- PMID: 22797
Item in Clipboard
[Changes of serum and urinary uric-acid levels after portacaval anastomosis in the rat]
[Article in
German]
Langenbecks Arch Chir.
1976.
Abstract
Significantly higher levels of uric acid in serum and urine together with increased urine volume and pH were observed in rats after portacaval end-to-side anastomosis in comparison to sham-operated and non-operated pair-fed controls. An increased supply of endogenous uric acid by reduced transformation of uric acid to allantoin and decreased uricase activity in the liver was assumed. Adaptation of enzyme activities of other metabolic pathways of the liver after PCA due to diminished blood and oxygen supply were described in previous experiments. This model seems suitable for other studies on hyperuricemia, hyperuricosuria and uric acid lithiasis.
Similar articles
-
The defect of uric acid metabolism in Eck-fistula rats.J Lab Clin Med. 1977 Jul;90(1):92-100. J Lab Clin Med. 1977. PMID: 17644
-
[Urolithiasis, an unexpected sequela of portacaval anastomosis].Z Gastroenterol. 1973 Mar;11(2):117-20. Z Gastroenterol. 1973. PMID: 4803409 German. No abstract available.
-
[Increase in urinary uric acid in the rat following portacaval shunt. The action of clofibrate].Ann Urol (Paris). 1985;19(2):128-31. Ann Urol (Paris). 1985. PMID: 4015051 French.
-
Uric acid: bystander or culprit in hypertension and progressive renal disease?J Hypertens. 2008 Nov;26(11):2085-92. doi: 10.1097/HJH.0b013e32830e4945. J Hypertens. 2008. PMID: 18854744 Review.
-
Novel insights into the pathogenesis of uric acid nephrolithiasis.Curr Opin Nephrol Hypertens. 2004 Mar;13(2):181-9. doi: 10.1097/00041552-200403000-00006. Curr Opin Nephrol Hypertens. 2004. PMID: 15202612 Review.