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. 1990 Dec;71(4):493-6.

Production of interleukin-1 by draining lymph node cells during the induction phase of contact sensitization in mice

S J Hopkins  1 , M Humphreys, A Kinnaird, D A Jones, I Kimber
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Production of interleukin-1 by draining lymph node cells during the induction phase of contact sensitization in mice

S J Hopkins et al. Immunology. 1990 Dec.

Abstract

Biologically active interleukin-1 (IL-1) has been detected in supernatants of draining lymph node cells isolated from contact-sensitized mice. Induction of IL-1 was dependent upon the concentration of sensitizer applied and occurred within 2 hr of exposure. The IL-1 activity could not be attributed to other interleukins and was neutralized by a specific antiserum. Reduced concentrations of IL-1 were produced by cells isolated from the draining nodes of mice that had been pre-exposed to the sensitizer. Since IL-1 has the potential to influence several aspects of lymphocyte activation, the production of significant concentrations of biologically active IL-1 by draining lymph node cells indicates that it is likely to play an important role in the afferent phase of contact sensitization.

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