Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug 14;28(32):11834-42.
doi: 10.1021/la3024716. Epub 2012 Jul 30.

Ultra magnetic liposomes for MR imaging, targeting, and hyperthermia

Gaëlle Béalle  1 , Riccardo Di Corato, Jelena Kolosnjaj-Tabi, Vincent Dupuis, Olivier Clément, Florence Gazeau, Claire Wilhelm, Christine Ménager
Affiliations

Ultra magnetic liposomes for MR imaging, targeting, and hyperthermia

Gaëlle Béalle et al. Langmuir. .

Abstract

Magnetic liposomes offer opportunities as theranostic systems. The prerequisite for efficient imaging, tissue targeting or hyperthermia is high magnetic load of these vesicles. Here we describe the preparation of Ultra Magnetic Liposomes (UMLs), which may encapsulate iron oxide nanoparticles in a volume fraction of up to 30%. This remarkable magnetic charge provides UMLs with high magnetic mobilities, MRI relaxivities, and heating capacities for magnetic hyperthermia. Moreover, these UMLs are rapidly and efficiently internalized by cultured tumor cells and, when they are administered to mice, they can be vectorized to tumors by an external magnet.

PubMed Disclaimer

Publication types