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Meta-Analysis
. 2012 Jul 16:12:289.
doi: 10.1186/1471-2407-12-289.

Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

Yanming Zhou  1 , Yanfang Zhao, Bin Li, Jiyi Huang, Lupeng Wu, Donghui Xu, Jiamei Yang, Jia He
Affiliations
Meta-Analysis

Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

Yanming Zhou et al. BMC Cancer. .

Abstract

Background: Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship.

Methods: A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0.

Results: Thirteen case-control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case-control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively.

Conclusions: This study suggests that both HBV and HCV infection are associated with an increased risk of ICC.

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Figures

Figure 1
Figure 1
Literature flow chart.
Figure 2
Figure 2
Forest plot of intrahepatic cholangiocarcinoma risk associated with HBV infection.
Figure 3
Figure 3
Forest plot of intrahepatic cholangiocarcinoma risk associated with HCV infection.
Figure 4
Figure 4
Funnel plot of studies evaluating the association between HBV infection and intrahepatic cholangiocarcinoma risk.
See this image and copyright information in PMC

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