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Editorial
. 2012 Aug 1;11(15):2763-4.
doi: 10.4161/cc.21254. Epub 2012 Aug 1.

Cdk1 drives meiosis and mitosis through two different mechanisms

Deepak Adhikari, Kui Liu, Yan Shen
Editorial

Cdk1 drives meiosis and mitosis through two different mechanisms

Deepak Adhikari et al. Cell Cycle. .

Abstract

Comment on: Adhikari D, et al. Hum Mol Gene 2012; 21:2476-84.

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Figures

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Figure 1. Schematic illustration of the roles of Cdk1 during the G2-M transition in mitosis and in the germinal vesicle breakdown that occurs during resumption of meiosis. (A) Cdk1 kinase is activated and promotes the phosphorylation of mitotic phosphoproteins at the G2-M transition in mitosis. In order to maintain the phosphorylation status of the Cdk1 substrates, PP2A is inactivated by activation of Gwl by Cdk1. Active Gwl inhibits PP2A through the activation of Arpp19 and Ensa. (B) During the resumption of meiosis in oocytes, Cdk1 is activated and promotes the phosphorylation of meiotic phosphoproteins. Maintenance of the phosphorylation status of the meiotic phosphoproteins is ensured by phosphorylation and inhibition of PP1 by Cdk1. P, phosphorylation; Arpp19, cAMP-regulated phosphoprotein 19; Ensa, α-endosulfine.
See this image and copyright information in PMC

Comment in

  • Adhikari D, Zheng W, Shen Y, Gorre N, Ning Y, Halet G, Kaldis P, Liu K. Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes. Hum Mol Genet. 2012;21:2476–84. doi: 10.1093/hmg/dds061.

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