Stenotic coexistence among coronary, renal and extracrainal arteries in Chinese patients

Abstract

To investigate the stenotic coexistence among coronary, renal and extracranial arteries and check the predictive value of stenosis between these arteries in Chinese patients. The stenosis of three arteries was evaluated by angiography in 1,228 Chinese patients with clinically diagnosed coronary artery disease (CAD) or high CAD risk factors. Based on the criteria of stenotic diameter of ≥50%, we found that the rate of stenosis for the coronary artery was highest (48.5%), extracranial artery stenosis rate was intermediate at 20.2% and the renal artery with the stenosis rate of 14.3% was the lowest. The stenotic coexistence rates were 14.3% between the coronary and extracranial arteries, 10.9 % between coronary and renal arteries, 10.1% between the extracranial and renal arteries, and only 2.69% among all three arteries. The stenosis predictive value of the coronary artery for extracranial or renal arteries was lower, but the non-stenosis predictive value was higher. The predictive value of extracranial or renal artery for coronary artery stenosis was higher, while the non-stenosis predictive value was lower. Both the stenosis and non-stenosis predictive values were higher between the extracranial and renal arteries. Cohen's Kappa value was less than 0.40 between coronary and extracrainal or renal artery but more than 0.40 between extracranial and renal artery. The results were similar when the criteria of stenosis were judged as ≥75 or ≥25% respectively. We also did analysis within the subgroups with hypertension, diabetes, stroke and transient ischemia attach, got similar results. For Chinese patients with clinically diagnosed CAD or with highly risk factors, non-stenosis of the coronary artery is indicative of reduced stenosis of the extracranial and renal arteries, while extracranial or renal arteries stenosis is indicative of increased coronary artery stenosis.