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Case Reports
. 2010 Dec 20:2010:bcr0520102993.
doi: 10.1136/bcr.05.2010.2993.

Successful treatment of methimazole-induced severe aplastic anaemia in a diabetic patient with other co-morbidities

Cindy V Josol  1 , Myrna Buenaluz-Sedurante, Mark Anthony Sandoval, Gerry Castillo
Affiliations
Case Reports

Successful treatment of methimazole-induced severe aplastic anaemia in a diabetic patient with other co-morbidities

Cindy V Josol et al. BMJ Case Rep. .

Abstract

A 55-year-old Filipina with Grave's disease, diabetes, hypertension, bronchial asthma, Parkinson's disease and a history of adverse drug reaction to penicillin consulted due to high-grade fever and sore throat. Patient was diagnosed with aplastic anaemia secondary to methimazole and was treated with high-dose granulocyte colony stimulating factor, thrombopoietin and mesterolone. Antibiotics used included levofloxacin, clindamycin, amikacin and fluconazole. Due to bleeding and slow recovery of blood parameters, 30 units of platelets and 7 units of packed red blood cells were transfused during her 22-day admission. This case presents a life-threatening adverse drug reaction in a patient with co-morbid conditions that complicate recovery and limit one's therapeutic options.

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Conflict of interest statement

Competing interests None.

Figures

Figure 1
Figure 1
Evolution of granulocyte count during granulocyte colony stimulating factor (G-CSF) treatment.
Figure 2
Figure 2
Platelet count during treatment.
See this image and copyright information in PMC

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