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. 2012 Jan;152(3):329-32.
doi: 10.1007/s10517-012-1520-3.

Tissue-specific expression of splice variants of human IL-4 and IL-6 gene mRNA

O P Yatsenko  1 , A N Silkov, E A Khrapov, M L Filipenko, V A Kozlov, S V Sennikov
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Tissue-specific expression of splice variants of human IL-4 and IL-6 gene mRNA

O P Yatsenko et al. Bull Exp Biol Med. 2012 Jan.

Abstract

The spectrum of alternatively spliced IL-4 and IL-6 gene mRNA was studied in peripheral blood mononuclears from healthy donors and in human fetal tissues. It was found that the expression of alternatively spliced IL-4 and IL-6 gene mRNA in fetal tissues is tissue specific and that hemopoiesis- and immunopoiesis-related tissues differ by the amount of IL-4 and IL-4δ2 mRNA. An mRNA variant IL-4alt3 carrying partial exon 3 deletion was for the first time identified in human mononuclear cells.

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