Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Oct;79(10):919-24.
doi: 10.1002/jps.2600791016.

Lactic acid oligomer microspheres containing hydrophilic drugs

R Wada  1 , S H Hyon, Y Ikada
Affiliations

Lactic acid oligomer microspheres containing hydrophilic drugs

R Wada et al. J Pharm Sci. 1990 Oct.

Abstract

A new method was developed for preparation of biodegradable lactic acid oligomer microspheres containing hydrophilic drugs. The microspheres were obtained by removal of solvent from an O/O (oil-in-oil) emulsion through evaporation. The solvent used for the dispersed phase solution was an acetonitrile: water mixture, while the continuous phase medium was cottonseed oil. Doxorubicin hydrochloride (ADR) and insulin were successfully entrapped in the microspheres with high trapping efficiencies of 80 to 90%, and their release profiles were not accompanied with the significant burst effect. The release rate of the drugs from the microspheres was greatly affected by the initial loading of the drugs and the molecular weight of the lactic acid oligomer.

PubMed Disclaimer