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. 2012 Nov;6(6):e169-77.
doi: 10.1111/j.1750-2659.2012.00408.x. Epub 2012 Jul 16.

Epidemiology of influenza A (H1N1)pdm09-associated deaths in the United States, September-October 2009

Joanna Regan  1 , Ashley Fowlkes, Matthew Biggerstaff, Michael A Jhung, Jacqueline Gindler, Erin Kennedy, Victoria Fields, Lyn Finelli; 2009 Pandemic Influenza A (H1N1) Fatal Case Series Investigation Team
Collaborators, Affiliations

Epidemiology of influenza A (H1N1)pdm09-associated deaths in the United States, September-October 2009

Joanna Regan et al. Influenza Other Respir Viruses. 2012 Nov.

Abstract

Background: From April to July 2009, the United States experienced a wave of influenza A (H1N1)pdm09 virus (H1N1pdm09) infection. The majority of the deaths during that period occurred in persons <65 years of age with underlying medical conditions.

Objective: To describe the epidemiology of H1N1pdm09-associated deaths in the US during the fall of 2009.

Methods: We collected demographic, medical history, and cause of death information on a nationally representative, stratified random sample of 323 H1N1pdm09-associated deaths that occurred during September 1-October 31, 2009.

Results: Data were available for 302/323 (93%) deaths. Most cases (74%) were 18-64 years of age and had ≥ 1 underlying medical condition (72%). Among cases aged <18 years, 16/43 (37%) had a chronic lung disease, and 15/43 (35%) a neurological disorder; among cases aged ≥ 18 years, 94/254 (37%) had a chronic lung disease and 84/254 (33%) had a metabolic disorder. The median number of days between symptom onset and death was six among children (range, 1-48) and 12 among adults (range, 0-109). Influenza antiviral agents were prescribed for 187/268 (70%) of cases, but only 48/153 (31%) received treatment within 2 days of illness onset.

Conclusions: The characteristics of H1N1pdm09 deaths identified during the fall of 2009 were similar to those occurring April-July 2009. While most cases had conditions that were known to increase the risk for severe outcomes and were recommended to receive antiviral therapy, a minority of cases received antivirals early in the course of illness.

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Figures

Figure 1
Figure 1
Influenza A (H1N1)pdm09‐associated deaths, by age group, United States, September 1–October 31, 2009.
See this image and copyright information in PMC

References

    1. Novel Swine‐Origin Influenza A (H1N1) Virus Investigation Team . Emergence of a novel swine‐origin influenza A (H1N1) virus in humans. N Engl J Med 2009; 360:2605–2615. - PubMed
    1. Jhung M, Swerdlow D, Olsen S et al. Epidemiology of 2009 Pandemic Influenza A (H1N1) in the United States. Clin Infect Dis 2011; 52(Suppl 1):S13–S26. - PubMed
    1. Thompson WW, Shay DK, Weintraub E et al. Mortality associated with influenza viruses and respiratory syncytial virus in the United States. JAMA 2003; 289:170–186. - PubMed
    1. Centers for Disease Control and Prevention . Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm Rep 2009; 58:1–54. - PubMed
    1. Fowlkes A, Arguin P, Biggerstaff M et al. Epidemiology of 2009 Pandemic Influenza A (H1N1) deaths in the United States, April–July 2009. Clin Infect Dis 2011; 52(Suppl 1):860–868. - PubMed

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