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. 2012 Jul 17:12:53.
doi: 10.1186/1471-2261-12-53.

Coronary artery calcium findings in asymptomatic subjects with family history of premature coronary artery disease

Catalin Taraboanta  1 , Cameron J Hague, G B John Mancini, Bruce B Forster, Jiri Frohlich
Affiliations

Coronary artery calcium findings in asymptomatic subjects with family history of premature coronary artery disease

Catalin Taraboanta et al. BMC Cardiovasc Disord. .

Abstract

Background: To evaluate the frequency of positive coronary arteries calcium (CAC) scores in a unique population of asymptomatic first degree relatives (FDRs) of patients with angiographically confirmed early onset of coronary artery disease (CAD) and to assess their association with carotid ultrasound findings and other cardiovascular risk factors.

Method and results: We scanned, using 64-slice multi-detector computed tomography, 57 asymptomatic FDRs (47 ± 9 years old; 44% male, 56% female), out of the 111 FDRs previously phenotyped for cardiovascular (CV) risk factors. The controls were 616 individuals (57 ± 10 years old; 76% male, 24% female) with no family history of cardiovascular disease, chest pain or diabetes selected out of the 3500 subjects scanned between 2002 and 2007. FDRs had higher risk of abnormal CAC scores compared to controls; odds ratio (OR) for the 75th percentile was 1.96 (95% CI 1.04-3.67, p < 0.05).

Conclusion: The frequency of abnormal CAC scores is two-fold higher in asymptomatic FDRs than in controls. CAC scan provides additional information on CV risk assessment in asymptomatic FDRs, particularly for those in the intermediate risk category.

Clinical trial registration: NCT00387595.

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Figures

Figure 1
Figure 1
FDRs cardiovascular risk as defined by Framingham Risk Score, presence of subclinical atherosclerosis in either carotid or coronary arteries and negative calcium scoring scan*.
See this image and copyright information in PMC

References

    1. Barrett-Connor E, Khaw K. Family history of heart attack as an independent predictor of death due to cardiovascular disease. Circulation. 1984;69(6):1065–1069. doi: 10.1161/01.CIR.69.6.1065. - DOI - PubMed
    1. Shea SOR, Gabrieli C, Stein Z, Nichols A. Family history as an independent risk factor for coronary artery disease. J Am Coll Cardiol. 1984;4:793–801. doi: 10.1016/S0735-1097(84)80408-8. - DOI - PubMed
    1. Friedlander Y, Kark JD, Stein Y. Family history of myocardial infarction as an independent risk factor for coronary heart disease. Br Heart J. 1985;53(4):382–387. doi: 10.1136/hrt.53.4.382. - DOI - PMC - PubMed
    1. Hopkins PN, Williams RR, Kuida H, Stults BM, Hunt SC, Barlow GK. et al.Family history as an independent risk factor for incident coronary artery disease in a high-risk cohort in Utah. Am J of Cardiol. 1988;62(10 Pt 1):703–707. - PubMed
    1. Andresdottir MB, Sigurdsson G, Sigvaldason H, Gudnason V. Fifteen percent of myocardial infarctions and coronary revascularizations explained by family history unrelated to conventional risk factors. The Reykjavik Cohort Study. Eur Heart J. 2002;23(21):1655–1663. - PubMed

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